PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-GAMMA - ADIPOSE-PREDOMINANT EXPRESSION AND INDUCTION EARLY IN ADIPOCYTE DIFFERENTIATION

被引：774
|
作者：
CHAWLA, A [1 ]
SCHWARZ, EJ [1 ]
DIMACULANGAN, DD [1 ]
LAZAR, MA [1 ]
机构：
[1] UNIV PENN,SCH MED,DEPT GENET,PHILADELPHIA,PA 19104
来源：
ENDOCRINOLOGY | 1994年 / 135卷 / 02期
关键词：
D O I：
10.1210/en.135.2.798
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Activators of peroxisome proliferator activated receptor (PPAR) regulate fatty acid metabolism and can induce adipocyte differentiation. We show here that the gamma subtype of PPAR is expressed at high levels in adipose tissue in contrast to a variety of other tissues, where little gene expression was noted. In addition, PPAR gamma is present at low levels in 3T3-L1 preadipocytes and is induced dramatically during adipocyte conversion using either normal differentiating conditions (fetal calf serum, dexamethasone, isobutylmethylxanthine, and insulin) or the PPAR activator, WY-14,643. Thus PPAR gamma may be important for adipose cell development and function.
引用
收藏
页码：798 / 800
页数：3
相关论文
共 50 条
  • [21] Peroxisome proliferator-activated receptor γ (PPARγ) and sepsis
    von Knethen, Andreas
    Soller, Mathias
    Bruene, Bernhard
    ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2007, 55 (01) : 19 - 25
  • [22] Peroxisome proliferator-activated receptor γ (PPARγ) and sepsis
    Andreas von Knethen
    Mathias Soller
    Bernhard Brüne
    Archivum Immunologiae et Therapiae Experimentalis, 2007, 55 : 19 - 25
  • [23] Peroxisome proliferator-activated receptor δ (PPARδ) in psoriasis
    Westergaard, M
    Henningsen, J
    Johansen, C
    Svendsen, ML
    Iversen, L
    Bolund, L
    Kragballe, K
    Kristiansen, K
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 115 (03) : 582 - 582
  • [24] Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: Regulation by peroxisome proliferator-activated receptor gamma
    Sears, IB
    MacGinnitie, MA
    Kovacs, LG
    Graves, RA
    MOLECULAR AND CELLULAR BIOLOGY, 1996, 16 (07) : 3410 - 3419
  • [25] Initiation of the expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) in the rat ovary and the role of FSH
    Long, Mary J.
    Sairam, M. Ram
    Komar, Carolyn M.
    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2009, 7
  • [26] Novel expression and function of peroxisome proliferator-activated receptor gamma (PPARγ) in human neuroblastoma cells
    Han, SW
    Greene, ME
    Pitts, J
    Wada, RK
    Sidell, N
    CLINICAL CANCER RESEARCH, 2001, 7 (01) : 98 - 104
  • [27] Adipocyte differentiation is regulated by a prostaglandin liganded to the nuclear peroxisome proliferator-activated receptor
    Wolf, G
    NUTRITION REVIEWS, 1996, 54 (09) : 290 - 292
  • [28] Expression of the peroxisome proliferator-activated receptor (PPAR) in the mouse colonic mucosa
    Mansen, A
    GuardiolaDiaz, H
    Rafter, J
    Branting, C
    Gustafsson, JA
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 222 (03) : 844 - 851
  • [29] REGULATION OF ADIPOCYTE GENE-EXPRESSION AND DIFFERENTIATION BY PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-GAMMA
    TONTONOZ, P
    HU, E
    SPIEGELMAN, BM
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 1995, 5 (05) : 571 - 576
  • [30] Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer
    Segawa, Y
    Yoshimura, R
    Hase, T
    Nakatani, T
    Wada, S
    Kawahito, Y
    Kishimoto, T
    Sano, H
    PROSTATE, 2002, 51 (02): : 108 - 116
12345