PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-GAMMA - ADIPOSE-PREDOMINANT EXPRESSION AND INDUCTION EARLY IN ADIPOCYTE DIFFERENTIATION

被引：774

作者：

CHAWLA, A ^{[1
]}

SCHWARZ, EJ ^{[1
]}

DIMACULANGAN, DD ^{[1
]}

LAZAR, MA ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT GENET,PHILADELPHIA,PA 19104

来源：

ENDOCRINOLOGY | 1994年 / 135卷 / 02期

关键词：

D O I：

10.1210/en.135.2.798

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activators of peroxisome proliferator activated receptor (PPAR) regulate fatty acid metabolism and can induce adipocyte differentiation. We show here that the gamma subtype of PPAR is expressed at high levels in adipose tissue in contrast to a variety of other tissues, where little gene expression was noted. In addition, PPAR gamma is present at low levels in 3T3-L1 preadipocytes and is induced dramatically during adipocyte conversion using either normal differentiating conditions (fetal calf serum, dexamethasone, isobutylmethylxanthine, and insulin) or the PPAR activator, WY-14,643. Thus PPAR gamma may be important for adipose cell development and function.

引用

页码：798 / 800

页数：3

共 14 条

[1] STEROID-RECEPTOR FAMILY - STRUCTURE AND FUNCTIONS
CARSONJURICA, MA
SCHRADER, WT
OMALLEY, BW
[J]. ENDOCRINE REVIEWS, 1990, 11 (02) : 201 - 220
[2] CHAWLA A, 1993, J BIOL CHEM, V268, P16265
[3] PEROXISOME PROLIFERATOR AND RETINOID SIGNALING PATHWAYS COREGULATE PREADIPOCYTE PHENOTYPE AND SURVIVAL
CHAWLA, A
LAZAR, MA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (05) : 1786 - 1790
[4] IDENTIFICATION OF 2 MESSENGER PPAR RELATED RECEPTORS AND EVIDENCE FOR THE EXISTENCE OF 5 SUBFAMILY MEMBERS
CHEN, F
LAW, SW
OMALLEY, BW
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 196 (02) : 671 - 677
[5] CCAAT ENHANCER BINDING-PROTEIN GENE PROMOTER - BINDING OF NUCLEAR FACTORS DURING DIFFERENTIATION OF 3T3-L1 PREADIPOCYTES
CHRISTY, RJ
KAESTNER, KH
GEIMAN, DE
LANE, MD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) : 2593 - 2597
[6] DREYER C, 1992, ELL, V68, P879
[7] THE STEROID AND THYROID-HORMONE RECEPTOR SUPERFAMILY
EVANS, RM
[J]. SCIENCE, 1988, 240 (4854) : 889 - 895
[8] PEROXISOME PROLIFERATORS - PARADIGMS AND PROSPECTS
GIBSON, GG
[J]. TOXICOLOGY LETTERS, 1993, 68 (1-2) : 193 - 201
[9] NUCLEAR RECEPTORS ENHANCE OUR UNDERSTANDING OF TRANSCRIPTION REGULATION
GREEN, S
CHAMBON, P
[J]. TRENDS IN GENETICS, 1988, 4 (11) : 309 - 314
[10] ISSEMANN I, 1990, NATURE, V347, P645, DOI 10.1038/347645a0

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