FAMILIAL BREAST-OVARIAN CANCER LOCUS ON CHROMOSOME-17Q12-Q23

被引：2

作者：

NAROD, SA

FEUNTEUN, J

LYNCH, HT

WATSON, P

CONWAY, T

LYNCH, J

LENOIR, GM

机构：

[1] INT AGCY RES CANC,150 COURS ALBERT THOMAS,F-69372 LYONS,FRANCE

[2] MCGILL UNIV,DEPT ONCOL,MONTREAL H3G 1A4,QUEBEC,CANADA

[3] MCGILL UNIV,DEPT MED,MONTREAL H3G 1A4,QUEBEC,CANADA

[4] CREIGHTON UNIV,SCH MED,DEPT PREVENT MED,OMAHA,NE 68178

[5] MCGILL UNIV,CTR HUMAN GENET,MONTREAL H3G 1A4,QUEBEC,CANADA

[6] INST GUSTAVE ROUSSY,CNRS,UA 1158,F-94805 VILLEJUIF,FRANCE

来源：

LANCET | 1991年 / 338卷 / 8759期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Familial breast cancer has been linked to the D17S74 locus on chromosome 17q. To confirm this finding and to investigate whether ovarian cancer is also linked to this locus, five large families with a hereditary predisposition to cancer of the breast and ovary were investigated. Three families were positive for linkage. For the largest family the lod score was 2.72. These findings suggest that the chromosomal region 17q12-q23, previously shown to contain a gene for early-onset breast cancer, is also associated with a proportion of hereditary ovarian cancers.

引用

页码：82 / 83

页数：2

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