5-FLUOROURACIL, ADRIAMYCIN, AND MITOMYCIN-C (FAM) CHEMOTHERAPY FOR ADENOCARCINOMA OF THE LUNG

被引：0

作者：

BUTLER, TP ^{[1
]}

MACDONALD, JS ^{[1
]}

SMITH, FP ^{[1
]}

SMITH, LF ^{[1
]}

WOOLLEY, PV ^{[1
]}

SCHEIN, PS ^{[1
]}

机构：

[1] GEORGETOWN UNIV HOSP,VINCENT T LOMBARDI CANC RES CTR,DIV MED ONCOL,WASHINGTON,DC 20007

来源：

CANCER | 1979年 / 43卷 / 04期

关键词：

D O I：

10.1002/1097-0142(197904)43:4<1183::AID-CNCR2820430404>3.0.CO;2-Z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty‐five patients with advanced measurable adenocarcinoma of the lung were treated with combination chemotherapy consisting of 5‐fluorouracil, adriamycin, and mitomycin‐C (FAM). Objective response (1CR, 8PR) was obtained in 36% of patients. The median duration of response was 7.0 months and the median survival for responders is greater than 8.5 months. Five responders are alive 5.5 to 23.5 months after starting therapy. Three of four patients evidencing stabilization of disease are alive at 10–23 months. Nonresponding patients had a median survival of 2.5 months and none lived beyond seven months. Tumor response and survival suggested correlation with initial performance status and limited disease. The FAM regimen was tolerated well, with moderate bone marrow suppression and gastrointestinal symptoms being the only clinically significant toxicities. These results indicate that patients with advanced pulmonary adenocarcinoma can obtain objective tumor regression with FAM chemotherapy. Copyright © 1979 American Cancer Society

引用

页码：1183 / 1188

页数：6

共 20 条

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