Comparison between the Efficacy of Intra-Lesional Triamcenolone and Combination of Triamcinolone With 5-Fluorouracil in the Treatment of Keloid and Hypertrophic Scars

Aim: To compare the efficacy of intra-lesionaltriamcenolone combined with 5-fluorouracil versus triamcenolone alone in the treatment of keloids and hypertrophic scars Methods: This randomized controlled trial was conducted at Department of Plastic Surgery& Burn Unit, Sheikh Zaid Hospital Rahim Yar Khan from May 2015 to November 2015. Total 62 patients with keloid or hypertrophic scar measuring >1 cm in size, either male or female having age 15-60 years were selected for the study. Results: The mean age of patients in group A was 31.71 +/- 8.13years and in group B was 32.01 +/- 7.87years. Out of 62 patients, 61.29% were females and 38.71% were males with male to female ratio of 1.58:1. Efficacy of Group A (intra-lesionaltriamcenolone combined with 5-fluorouracil) was 64.52% while in Group B (intra-lesionaltriamcenolone alone) was 29.03% with p-value = 0.005 which is statistically significant. Conclusion: This studyconcluded that intra-lesionaltriamcenolone combined with 5-fluorouracil is better and more efficacious than intra-lesionaltriamcenolone alone in the treatment of keloids and hypertrophic scars.