GLOMERULAR VOLUME AND RENAL-FUNCTION IN CHILDREN WITH DIFFERENT TYPES OF THE NEPHROTIC SYNDROME

被引：21

作者：

NYBERG, E ^{[1
]}

BOHMAN, SO ^{[1
]}

BERG, U ^{[1
]}

机构：

[1] DANDERYD HOSP,DEPT PAEDIAT,STOCKHOLM,SWEDEN

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 03期

关键词：

GLOMERULAR VOLUME; RENAL FUNCTION; NEPHROTIC SYNDROME; GLOMERULAR FILTRATION RATE; RENAL HEMODYNAMICS; FOCAL SEGMENTAL GLOMERULOSCLEROSIS;

D O I：

10.1007/BF00866336

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Glomerular hypertrophy has been suggested to be an important factor in the pathogenesis of focal glomerular sclerosis. The aim of the present study was to analyse retrospectively the renal biopsies of 58 children (0.2-16.1 years of age) with different types of the nephrotic syndrome, minimal change nephrotic syndrome (MCNS), diffuse mesangial proliferation (DMP) and focal segmental glomerulosclerosis (FSGS). Glomerular surface area was measured and glomerular volume was calculated and related to steroid responsiveness and to renal function, measured by clearances of inulin and para-aminohippuric acid. Glomerular volume correlated with body surface area (BSA) and age. Because of this, patients with FSGS and DMP were matched according to BSA and age, with corresponding MCNS patients. Glomerular volumes of FSGS and DMP patients were significantly larger than those of MCNS patients. In the MCNS patients, significant correlations were found between glomerular volumes and glomerular filtration rate and effective renal plasma flow. Steroid-dependent and steroid-resistant patients showed larger glomeruli than the steroid-responsive children. We suggest that hyperfiltration and hyperperfusion, among other factors, may contribute to glomerular hypertrophy, mesangial proliferation and glomerulosclerosis.

引用

页码：285 / 289

页数：5

共 31 条

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