SCHIZOPHRENICS WITH SMALL P300 - A SUBGROUP WITH A NEURODEVELOPMENTAL DISTURBANCE AND A HIGH-RISK FOR TARDIVE-DYSKINESIA

被引:46
作者
HEGERL, U
JUCKEL, G
MULLERSCHUBERT, A
PIETZCKER, A
GAEBEL, W
机构
[1] FREE UNIV BERLIN,DEPT PSYCHIAT,W-1000 BERLIN,GERMANY
[2] UNIV DUSSELDORF,DEPT PSYCHIAT,W-4000 DUSSELDORF,GERMANY
关键词
AUDITORY EVOKED POTENTIAL; TARDIVE DYSKINESIA; SCHIZOPHRENIA; NEURODEVELOPMENT;
D O I
10.1111/j.1600-0447.1995.tb09751.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Schizophrenics with a neurodevelopmental disturbance resulting in micro- and macroanatomical cortical abnormalities are supposed to form a subgroup clinically characterized by low premorbid adjustment, early onset, incomplete remission, poor outcome, male predominance and high risk for tardive dyskinesia. A small amplitude of the event-related P3 (P300) potential could be a marker of this subgroup, because the cortical neurons and their orderly laminar arrangement are crucial for the electrogenesis of P3. In a 2-year follow-up study, auditory evoked P3 was recorded in 89 stabilized schizophrenic outpatients. Patients who developed tardive dyskinesia during the follow-up had smaller P3 than matched controls. Furthermore, a small P3 was associated with low premorbid adjustment, pronounced residual symptoms, low relapse rate, and male predominance. These findings indicate that schizophrenic patients with a reduced P3 have a higher risk of developing tardive dyskinesia and correspond clinically to a schizophrenic subgroup with a supposedly neurodevelopmental disturbance.
引用
收藏
页码:120 / 125
页数:6
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