EVOLUTION OF GONADOTROPIN-RELEASING HORMONES

被引：101
作者：
KING, JA [1 ]
MILLAR, RP [1 ]
机构：
[1] GROOTE SCHUUR HOSP,CAPE TOWN 7925,SOUTH AFRICA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1992年 / 3卷 / 09期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/1043-2760(92)90113-F
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
GnRH was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, multiple molecular forms of the peptide have evolved, which have been coopted for a variety of regulatory functions: as a neurotransmitter in the central and sympathetic nervous systems, as a paracrine regulator in the gonads and placenta, and as an autocrine regulator in tumor cells. We review here the evolution of these variant forms of GnRH and their functions.
引用
收藏
页码：339 / 346
页数：8
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