NATURAL-KILLER-CELLS CARRY THE GERM-LINE CONFIGURATION OF THE T-CELL RECEPTOR DELTA-CHAIN GENE AND HETEROGENEOUSLY EXPRESS 6 DISTINCT DELTA-TRANSCRIPTS

被引：7

作者：

CARE, A

PELICCI, PG

MECCIA, E

FAGIOLI, M

TESTA, U

CICCONE, E

MORETTA, A

MORETTA, L

PESCHLE, C

机构：

[1] UNIV GENEVA, IST NAZL RIC CANC, CH-1211 GENEVA 4, SWITZERLAND

[2] UNIV PERUGIA, MONTELUCE POLICLIN, IST CLIN MED, I-06100 PERUGIA, ITALY

[3] UNIV GENEVA, IST ONCOL, CH-1211 GENEVA 4, SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 04期

关键词：

D O I：

10.1002/eji.1830200434

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Investigations on T cell receptor δ chain (TcR δ) gene expression in freshly isolated normal large granular lymphocytes, natural killer (NK) cell clones and NK bulk cultures revealed six Tδ transcripts (3.5, 3.1, 2.2, 2.0, 1.5 and 1.3 kb) which varied in number and relative abundance in the different samples. None of the six known Tδ variable regions was expressed and the Tδ locus was retained in its germ‐line configuration. The origin and significance of these NK‐associated Tδ transcripts are discussed. Copyright © 1990 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：939 / 942

页数：4

共 24 条

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