FAINTING PRECIPITATED BY COLLAPSE-FIRING OF VENOUS BARORECEPTORS

被引:46
作者
DICKINSON, CJ
机构
[1] Wolfson Institute of Preventive Medicine, St Bartholomew's Hospital Medical College, London, EC1M 6BQ, Charterhouse Square
关键词
D O I
10.1016/0140-6736(93)92008-H
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
I propose that fainting (vaso-vagal syncope) is caused by the sudden invagination of the walls of underfilled atria and great veins when their intraluminal pressure no longer exceeds intrathoracic pressure, leading to anomalous collapse-firing of veno-atrial stretch receptors. Impulses there from cause reflex systemic vasodilation and bradycardia, probably through a brainstem relay path involving opioids and possibly the A5 area of the medulla. The inappropriate increase of afferent atriovenous baroreceptor-nerve activity leads, by a vicious circle, to a sudden collapse of systemic arterial pressure. Activation of ventricular receptors is neither a probable nor a necessary cause of syncope, though it might be part of the response.
引用
收藏
页码:970 / 972
页数:3
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