VITAMIN-E RADICAL REACTION WITH ANTIOXIDANTS IN RAT-LIVER MEMBRANES

被引：17

作者：

HIRAMATSU, M ^{[1
]}

VELASCO, RD ^{[1
]}

PACKER, L ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,MEMBRANE BIOENERGET GRP,251 LSA,BERKELEY,CA 94720

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 06期

关键词：

VITAMIN-E; TOCOPHEROXY RADICAL; MEMBRANES; TJ-960; ASCORBATE; GLUTATHIONE; FREE RADICALS;

D O I：

10.1016/0891-5849(90)90122-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Japanese herbal medicine Sho-saiko-to-go-keishi-ka-shakuyaku-to (TJ-960) has been demonstrated to have an antioxidant action by quenching free radicals. The effects of TJ-960 on the tocopheroxy radicals generated by an arachidonic acid and lipoxygenase oxidation system were compared with those of the ascorbate and glutathione in vitamin E-enriched rat liver microsomes and submitochondrial membrane particles (SMP). Using electron spin resonance spectrometry, the disappearance of the tocopheroxy radicals after addition of glutathione and ascorbate was detected in microsomes and SMP, with ascorbate displaying a more potent action than glutathione. Addition of TJ-960 demonstrated a similar effect on the tocopheroxy radicals in microsomes and SMP. In the presence of TJ-960, ascorbate, and glutathione, the loss of vitamin E in the vitamin E-enriched microsomes of rat liver undergoing oxidation was slowed down. In this paper, we introduced TJ-960 as another replenisher of vitamin E in membrane, increasing the membrane's resistance against oxidative damage.

引用

页码：459 / 464

页数：6

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