REQUIREMENT OF A STABLE SECONDARY STRUCTURE FOR ANTIVIRAL ACTIVITY OF POLYNUCLEOTIDES

被引：112
作者：
DECLERCQ, E
MERIGAN, TC
机构：
[1] Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, CA
来源：
NATURE | 1969年 / 222卷 / 5199期
关键词：
D O I：
10.1038/2221148a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Several polyribonucleotides, both as single species and when annealed in pairs, are able to induce interferon production in mammalian cells and cellular resistance to virus infection. These studies suggest that a stable secondary, presumably multistranded structure is required for this activity. © 1969 Nature Publishing Group.
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页码：1148 / &
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