SELECTIVE DEPROTECTION OF ESTERS USING MAGNESIUM AND METHANOL

被引：28

作者：

XU, YC ^{[1
]}

LEBEAU, E ^{[1
]}

WALKER, C ^{[1
]}

机构：

[1] BIOCHEM PHARMA INC,LAVAL H7V 1B7,PQ,CANADA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)73392-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of magnesium metal in methanol for the deprotection of alkyl esters is described. This mild reagent also provides good to excellent selectivity to cleave different esters. The order of the reactivity of this reagent towards acyl cleavages was found to be: p-nitrobenzoate > acetate > benzoate > pivaloate >> trifluroacetamide.

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收藏

页码：6207 / 6210

页数：4

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