FORCED SWIMMING IN RATS - HYPOTHERMIA, IMMOBILITY AND THE EFFECTS OF IMIPRAMINE

被引：75
作者：
PORSOLT, RD
DENIEL, M
JALFRE, M
机构：
[1] Centre de Recherche Delalande, 92500 Rueil-Malmaison, 10, rue des Carrières
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 57卷 / 04期
关键词：
Amine depletors; Forced swimming; Hypothermia; Imipramine; Screening model for antidepressants;
D O I：
10.1016/0014-2999(79)90507-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Rats when forced to swim in a restricted space not only became immobile but showed marked hypothermia. The hypothermia was greater than that observed after reserpine or Ro 4-1284 and was not antagonized by imipramine at doses which significantly reduced immobility. Hypothermia induced by forced swimming can therefore be dissociated from the immobility occurring in these conditions and also from drug-induced hypothermia. © 1979.
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页码：431 / 436
页数：6
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