The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression

被引：9
作者：
Chang, Suhwan [1 ,2 ]
Sharan, Shyam K. [1 ]
机构：
[1] NCI, Mouse Canc Genet Program, Ctr Canc Res, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA
[2] Univ Ulsan, Coll Med, Asan Inst Life Sci, Dept Med,Grad Sch, Seoul, South Korea
来源：
TRANSCRIPTION-AUSTIN | 2013年 / 4卷 / 01期
基金：
美国国家卫生研究院;
关键词：
BRCA1; breast cancer; transcription; epigenetic regulation; micro RNA; miR-155;
D O I：
10.4161/trns.22600
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mutation in BRCA1 accounts for half of all familial breast cancer cases. Recent studies have shown its role in the epigenetic regulation of an oncogenic microRNA, revealing a novel mode of tumor suppression that is independent of its well-established role in DNA repair and cell cycle regulation.
引用
收藏
页码：24 / 28
页数：5
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