INDUCTION OF ERYTHROID DIFFERENTIATION IN MURINE ERYTHROLEUKEMIA CELLS BY N-SUBSTITUTED POLYMETHYLENE DIAMIDES

被引：10
作者：
HOZUMI, T
NOMURA, J
ISHIZAWA, M
机构：
[1] Tokyo Metropolitan Institute of Medical Science, Tokyo, 113, 3–18–22, Honkomagome, Bunkyo-ku
[2] Department of Hygiene, Faculty of Medicine, Kyushu University, Fukuoka, 812, Higashi-ku
来源：
INTERNATIONAL JOURNAL OF CANCER | 1979年 / 23卷 / 01期
关键词：
D O I：
10.1002/ijc.2910230121
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Various N‐substituted polymethylene diamides were synthesized and tested for their potency to induce erythroid differentiation in murine erythro‐leukemia cells. N,N,N′,N′‐tetramethyl‐1.6‐hexane‐dicarboxamide (IIc) was the most potent inducer among 15 compounds tested. The effectiveness of this compound was similar to that of hexamethylene bisacetamide(HMBA). HMBA has a different amide linkage order from that of IIc. HMBA and IIc at a concentration of 5 mM had similar effects on the cell growth rate and induced a similar frequency of benzidine‐positive cells. Hower, hemoglobin production was 1.5 times more effective with IIc. Polymethylene diester, diamide, dihydrazide and dianilide had no effect on the induction of hemoglobin synthesis. The N‐alkylated amide group appears to be required for induction of differentiation in murine erythroleukemia cells. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码：119 / 122
页数：4
相关论文
共 25 条
[1]  
ASCHAN O, 1898, CHEM BER, V31, P2344
[2]   BROMODEOXYURIDINE INHIBITION OF FRIEND LEUKEMIA CELL INDUCTION BY BUTYRIC-ACID - TIME COURSE OF INHIBITION, REVERSAL, AND EFFECT OF OTHER BASE ANALOGS [J].
BICK, MD ;
CULLEN, BR .
SOMATIC CELL GENETICS, 1976, 2 (06) :545-558
[3]  
BLAISE EE, 1910, B SOC CHIM, V5, P681
[4]  
CURTIUS T, 1900, J PRAKT CHEM, V62, P189
[5]  
CURTIUS T, 1896, CHEM BER, V29, P1166
[6]   INCREASE IN GLOBIN CHAINS AND GLOBIN MESSENGER-RNA IN ERYTHROLEUKEMIA CELLS IN RESPONSE TO HEMIN [J].
DABNEY, BJ ;
BEAUDET, AL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1977, 179 (01) :106-112
[7]  
DIONNEAU R, COMPTES RENDUS ACAD, V145, P127
[8]  
EBERT PS, 1976, CANCER RES, V36, P1809
[9]  
FRIEND C, 1971, P NATL ACAD SCI USA, V68, P378
[10]  
GANTTER F, 1880, CHEM BER, V13, P1165
123