Synthesis and Screening of Some Novel 2-[5-(Substitutedphenyl)[1,3,4] oxadiazol-2-yl]-benzoxazoles as Potential Antimicrobial Agents

被引:14
作者
Gadegoni, Hemalatha [1 ]
Manda, Sarangapani [2 ]
Rangu, Shivaprasad [3 ]
机构
[1] Jayamukhi Coll Pharm, Warangal 506332, AP, India
[2] Kakatiya Univ, Univ Coll Pharmaceut Sci, Warangal 506009, AP, India
[3] Kakatiya Univ, Dept Chem, Warangal 506009, AP, India
来源
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE | 2013年 / 57卷 / 02期
关键词
1,3,4-Oxadiazole; Benzoxazole; Antimicrobial activity; Antifungal activity; Nematicidal activity;
D O I
10.5012/jkcs.2013.57.2.221
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A series of some novel 2-[5-(substitutedphenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles were synthesized by using benzoxazole-2-carboxylic acid on reaction with thionyl chloride in presence of ethanol solvent at room temperature gave benzoxazole-2-carbonyl chloride, which is turned into benzoxazole-2-carboxylic acid hydrazide on reaction with hydrazine hydrate in ethanol solvent under reflux. The subsequent treatment of benzoxazole-2-carboxylic acid hydrazide with an appropriate aromatic carboxylic acid in presence of polyphosparic acid under reflux afforded the title compounds. The chemical structures of the newly synthesized compounds were elucidated by their IR, 1 H NMR and Mass spectral data analysis. Further the compounds are used to find out their ability towards anti microbial and nematicidal activity.
引用
收藏
页码:221 / 226
页数:6
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