INVITRO EFFECTS OF THYROXINE ON THE MECHANICAL-PROPERTIES OF ERYTHROCYTES

被引：16

作者：

BASKURT, OK ^{[1
]}

LEVI, E ^{[1
]}

TEMIZER, A ^{[1
]}

OZER, D ^{[1
]}

CAGLAYAN, S ^{[1
]}

DIKMENOGLU, N ^{[1
]}

ANDAC, SO ^{[1
]}

机构：

[1] UNIV HACETTEPE,FAC PHARM,DEPT ANALYT CHEM,ANKARA 06100,TURKEY

来源：

LIFE SCIENCES | 1990年 / 46卷 / 20期

关键词：

D O I：

10.1016/0024-3205(90)90464-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In vitro effects of thyroxine on erythrocyte deformability and mechanical fragility were observed. Deformability of erythrocytes was improved in a dose dependent manner by thyroxine. Mechanical hemolysis was found to be lower if thyroxine was included in erythrocyte suspensions at concentrations close to the physiological levels (10-9M). These changes might be related to the alterations of intracellular calcium concentration, as in the erythrocyte suspensions containing 10-9M thyroxine, intracellular calcium concentration was found to be 30 times lower than the control suspensions which did not contain thyroxine. Thyroxine also reduced the mechanical hemolysis ratio in calcium loaded cells. These observations suggest that thyroxine might play some role in the regulation of the mechanical properties of erythrocytes which might be mediated via the effects on calcium metabolism. © 1990.

引用

页码：1471 / 1477

页数：7

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