MORPHOLOGIC CHANGES IN EXTRA-OCULAR MUSCLES OF THE DYSTROPHIC HAMSTER

被引：4

作者：

PERCY, DH ^{[1
]}

THAKAR, JH ^{[1
]}

STRICKLAND, KP ^{[1
]}

机构：

[1] UNIV WESTERN ONTARIO,DEPT BIOCHEM,LONDON N6A 5C1,ONTARIO,CANADA

来源：

MUSCLE & NERVE | 1979年 / 2卷 / 04期

关键词：

D O I：

10.1002/mus.880020408

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cardiomyopathic hamsters (UM‐X7.1 strain) have demonstrable myopathy involving both skeletal and cardiac muscle. In addition, they have multiple ocular abnormalities. In this study, extraocular muscles were examined by light and electron microscopy. Changes observed within affected muscle fibers were variable and included coagulation necrosis, lysis of myofibrils, mitochondrial changes, and infiltration by phagocytic cells. Regenerative changes included duplication of myoblast nuclei, proliferation of sarcoplasmic reticulum, and myofibrillogenesis. The lesions are presumably myogenic in origin. The cardiomyopathic hamster may be useful as an animal model for certain types of ocular myopathy in man. Copyright © 1979 Houghton Mifflin Professional Publishers

引用

页码：288 / 294

页数：7

共 16 条

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