Expression Of Aggregation Capacity Of Platelets In Abdominal Obesity And Dyslipidemia.

被引:0
作者
Medvedev, I. N. [1 ]
机构
[1] Russian State Social Univ, St V Pika 4, Moscow 129226, Russia
来源
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES | 2018年 / 9卷 / 05期
关键词
platelets; abdominal obesity; dyslipidemia; aggregation; hemostasis;
D O I
暂无
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The gradual steady improvement of the process of rendering medical care to the population can not contain the growth in the world of prevalence of a combination of abdominal obesity and dyslipidemia. A particular danger of this condition is the high incidence of thrombosis development. This circumstance is commonly associated with hyperaggregation of blood cells, which has not been studied to the end. The goal is to assess the level of aggregation properties of platelets in patients with abdominal obesity and dyslipidemia. We examined 41 patients of the second adult age (mean age 49.2 +/- 1.8 years) with abdominal obesity and dyslipidemia. The control group consisted of 26 clinically healthy people of the same age. All the examinees gave written informed consent to participate in the study. Biochemical, hematological and statistical methods of investigation were used. The high incidence of thrombosis of various localizations with abdominal obesity and dyslipidemia is closely related to the development of angiopathy against their background. Weakening of antioxidant protection of blood plasma with the activation of lipid peroxidation processes that lead to a change in the vascular wall is noted in conditions of abdominal obesity and dyslipidemia. In individuals with abdominal obesity and dyslipidemia, a pronounced weakening of the disaggregating vascular effects of the vascular wall was shown to increase the aggregative capacity of thrombocytes. In individuals with abdominal obesity and dyslipidemia, a pronounced weakening of the disaggregating vascular effects of the vascular wall was shown to increase the aggregative capacity of thrombocytes. As a result of his patients, the risk of thrombosis of any localization increases sharply, which can lead to disability and death.
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页码:1941 / 1946
页数:6
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