BACTERICIDAL AND BACTERIOSTATIC ACTION OF CHLORAMPHENICOL AGAINST MENINGEAL PATHOGENS

被引：164

作者：

RAHAL, JJ ^{[1
]}

SIMBERKOFF, MS ^{[1
]}

机构：

[1] NYU,SCH MED,DEPT MED,NEW YORK,NY 10016

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 16卷 / 01期

关键词：

D O I：

10.1128/AAC.16.1.13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bacteriostatic and bactericidal effects of chloramphenicol, ampicillin, tetracycline, and sulfisoxazole were compared against several potential meningeal pathogens. Chloramphenicol is bactericidal at clinically achievable concentrations against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. It is bacteriostatic against gram-negative bacilli of the family Enterobacteriaceae and against Staphylococcus aureus. Chloramphenicol has proven highly efficacious in the treatment of bacterial meningitis caused by those organisms against which it is bactericidal at low concentrations. because leukocytic phagocytosis in the subarachnoid space is inefficient, we propose that bactericidal activity in cerebrospinal fluid is important for optimal therapy of bacterial meningitis. Chloramphenicol does not provide such activity in meningitis caused by enteric gram-negative bacilli.

引用

页码：13 / 18

页数：6

共 20 条

[1] COMPARISON OF THE ACTION OF STREPTOMYCIN, POLYMYXIN-B, AUREOMYCIN AND CHLOROMYCETIN ON H-PERTUSSIS, H-PARAPERTUSSIS, H-INFLUENZAE AND 5 ENTERIC STRAINS OF GRAM-NEGATIVE BACILLI [J].