Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of beta-amyloid(1-40) protein

被引：19

作者：

Yamada, K

Nitta, A

Saito, T

Hu, JG

Nabeshima, T

机构：

[1] BML INC,CTR RES & DEV,KAWAGOE,SAITAMA,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL & HOSP PHARM,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 201卷 / 02期

关键词：

beta-amyloid; Alzheimer's disease; ciliary neurotrophic factor; enzyme immunoassay; trophic factor; memory;

D O I：

10.1016/0304-3940(95)12161-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously shown that the continuous intracerebroventricular infusion of beta-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of beta-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The beta-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of beta-amyloid(1-40) in the brain may affect CNTF production in vivo.

引用

收藏

页码：155 / 158

页数：4

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