Biological treatment of severe/difficult asthma

被引:0
作者
Lukaszyk, Mateusz [1 ]
Jastrzebska, Ewelina [1 ]
Zietkowski, Ziemowit [2 ]
Bodzenta-Lukaszyk, Anna [2 ]
机构
[1] Uniwersytet Med Bialymstoku, Bialystok, Poland
[2] Uniwersytet Med Bialymstoku, Klin Alergol & Chorob Wewnetrznych, Ul M Sklodowskiej Curie 24, PL-15276 Bialystok, Poland
来源
ALERGIA ASTMA IMMUNOLOGIA | 2013年 / 18卷 / 02期
关键词
severe/difficult asthma; omalizumab; mepolizumab; lebrikizumab;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Asthma is a chronic inflammatory disease of the airways. Nearly 60% of asthma cases have allergic background. About 5-10% of patients treated for asthma do not respond well to standard treatment suggested by GINA 2006 guidelines. The article reviews the anti-IgE therapy for patients with severe/difficult asthma as well as points out the prospects of treatment with new biological drugs now being in 2nd and 3rd phase of clinical trials, which may play a significant role in severe asthma treatment in the near future.
引用
收藏
页码:86 / 90
页数:5
相关论文
共 36 条
[1]   Monoclonal antibodies for asthma and chronic obstructive pulmonary disease [J].
Antoniu, Sabina Antonela .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (02) :257-268
[2]   Severe asthma: Advances in current management and future therapy [J].
Barnes, Peter J. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (01) :48-59
[3]   Omalizumab: an anti-immunoglobulin E antibody for the treatment of allergic respiratory diseases [J].
Bousquet, J. ;
Wahn, U. ;
Meltzer, E. O. ;
Fox, H. ;
Hedgecock, S. ;
Thomas, K. ;
Fowler-Taylor, A. .
EUROPEAN RESPIRATORY REVIEW, 2008, 17 (107) :1-9
[4]   "Real-life" effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study [J].
Brusselle, G. ;
Michils, A. ;
Louis, R. ;
Dupont, L. ;
de Maele, B. Van ;
Delobbe, A. ;
Pilette, C. ;
Lee, C. S. ;
Gurdain, S. ;
Vancayzeele, S. ;
Lecomte, P. ;
Hermans, C. ;
MacDonald, K. ;
Song, M. ;
Abraham, I. .
RESPIRATORY MEDICINE, 2009, 103 (11) :1633-1642
[5]   Omalizumab and the risk of malignancy: Results from a pooled analysis [J].
Busse, William ;
Buhl, Roland ;
Vidaurre, Carlos Fernandez ;
Blogg, Martin ;
Zhu, Jin ;
Eisner, Mark D. ;
Canvin, Janice .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (04) :983-U482
[6]   Effect of omalizumab on symptoms of seasonal allergic rhinitis - A randomized controlled trial [J].
Casale, TB ;
Condemi, J ;
LaForce, C ;
Nayak, A ;
Rowe, M ;
Watrous, M ;
McAlary, M ;
Fowler-Taylor, A ;
Racine, M ;
Gupta, N ;
Fick, R ;
Della Cioppa, G .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (23) :2956-2967
[7]   Lebrikizumab Treatment in Adults with Asthma [J].
Corren, Jonathan ;
Lemanske, Robert F., Jr. ;
Hanania, Nicola A. ;
Korenblat, Phillip E. ;
Parsey, Merdad V. ;
Arron, Joseph R. ;
Harris, Jeffrey M. ;
Scheerens, Heleen ;
Wu, Lawren C. ;
Su, Zheng ;
Mosesova, Sofia ;
Eisner, Mark D. ;
Bohen, Sean P. ;
Matthews, John G. .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (12) :1088-1098
[8]  
Di Domenico Monica, 2011, Inflammation & Allergy Drug Targets, V10, P2
[9]   What effect does asthma treatment have on airway remodeling? Current perspectives [J].
Durrani, Sheharyar R. ;
Viswanathan, Ravi K. ;
Busse, William W. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (03) :439-448
[10]   Omalizumab [J].
Easthope, S ;
Jarvis, B .
DRUGS, 2001, 61 (02) :253-260