PROLACTIN INDUCES GROWTH-RELATED GENE-EXPRESSION IN RAT AORTIC SMOOTH-MUSCLE INVIVO

被引：11

作者：

SAURO, MD ^{[1
]}

BING, B ^{[1
]}

ZORN, NE ^{[1
]}

机构：

[1] UNIV S FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, TAMPA, FL 33612 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 225卷 / 04期

关键词：

PROLACTIN; SMOOTH MUSCLE (VASCULAR); GENE EXPRESSION; HYPERTENSION; C-MYC; ORNITHINE DECARBOXYLASE;

D O I：

10.1016/0922-4106(92)90110-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the effects of in vivo administration of prolactin on growth-related gene expression in aorta. Optimal mRNA expression for both the proto-oncogene, c-myc and ornithine decarboxylase occurred at 22 mg/kg prolactin. For c-myc, this was seen as early as 15 min. Prolactin-induced ornithine decarboxylase mRNA expression began at 1 h. The results confirm work showing induction of these genes by prolactin in tissues where it is mitogenic and supports a role for prolactin in the trophic response of vascular smooth muscle.

引用

页码：351 / 354

页数：4

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