PROLACTIN INDUCES GROWTH-RELATED GENE-EXPRESSION IN RAT AORTIC SMOOTH-MUSCLE INVIVO

被引：11
作者：
SAURO, MD [1 ]
BING, B [1 ]
ZORN, NE [1 ]
机构：
[1] UNIV S FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, TAMPA, FL 33612 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 225卷 / 04期
关键词：
PROLACTIN; SMOOTH MUSCLE (VASCULAR); GENE EXPRESSION; HYPERTENSION; C-MYC; ORNITHINE DECARBOXYLASE;
D O I：
10.1016/0922-4106(92)90110-H
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We examined the effects of in vivo administration of prolactin on growth-related gene expression in aorta. Optimal mRNA expression for both the proto-oncogene, c-myc and ornithine decarboxylase occurred at 22 mg/kg prolactin. For c-myc, this was seen as early as 15 min. Prolactin-induced ornithine decarboxylase mRNA expression began at 1 h. The results confirm work showing induction of these genes by prolactin in tissues where it is mitogenic and supports a role for prolactin in the trophic response of vascular smooth muscle.
引用
收藏
页码：351 / 354
页数：4
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