INTERLEUKIN-5 MODULATES EOSINOPHIL ACCUMULATION IN ALLERGIC GUINEA-PIG LUNG

被引：135

作者：

GULBENKIAN, AR ^{[1
]}

EGAN, RW ^{[1
]}

FERNANDEZ, X ^{[1
]}

JONES, H ^{[1
]}

KREUTNER, W ^{[1
]}

KUNG, T ^{[1
]}

PAYVANDI, F ^{[1
]}

SULLIVAN, L ^{[1
]}

ZURCHER, JA ^{[1
]}

WATNICK, AS ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP, RES INST, ALLERGY & CELL BIOL, 60 ORANGE ST, BLOOMFIELD, NJ 07003 USA

来源：

AMERICAN REVIEW OF RESPIRATORY DISEASE | 1992年 / 146卷 / 01期

关键词：

D O I：

10.1164/ajrccm/146.1.263

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Based on its involvement in eosinophil biology, interleukin 5 (IL-5) may play a role in the pulmonary eosinophilia associated with allergic reactions. We have examined that hypothesis using a neutralizing antibody to IL-5 in ovalbumin-sensitized guinea pigs challenged with serosolized antigen. The extent of eosinophilia has been quantitated in bronchoalveolar lavage (BAL) and by histologic evaluation of lung tissue sections. Acute intraperitoneal administration of a rat IgG, monoclonal antibody to murine IL-5 derived from TRFK-5 cells prevented lung and BAL eosinophilia in a dose-dependent fashion at and above 10-mu-g per guinea pig. Treatment with either an experimentally irrelevant, isotype-matched antibody from GL113 cells or with heat-denatured IL-5 antibody was without effect. These studies demonstrate the importance of IL-5 to pulmonary eosinophilia in challenged, allergic guinea pigs.

引用

页码：263 / 266

页数：4

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