SYNTHESIS OF PROTECTED FRAGMENTS OF THE CAPSULAR POLYSACCHARIDE FROM STREPTOCOCCUS-PNEUMONIAE TYPE-8

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CHERNYAK, AY

ANTONOV, KV

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BIOORGANICHESKAYA KHIMIYA | 1992年 / 18卷 / 05期

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Oxidation of acetates of ally] and 2-(benzyloxycarbonylamino)ethyl beta-cellobiosides (with OH-4' and OH-6' unprotected) with the Jones reagent followed by esterification (with diazomethane or phenyldiazomethane) gave corresponding uronates with OH-4' unsubstituted. Condensation of these glycosyl acceptors and benzylated derivatives of D-galactose or 4-O-(alpha-D-glucopyranosyl)-D-galactose led to the protected tri- and tetrasaccharide fragments of the capsular polysaccharide from Streptococcus pneumoniae type 8.

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页码：716 / 725

页数：10

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