ELECTROPHORESIS OF SERUM ISOENZYMES AND PROTEINS FOLLOWING ACUTE MYOCARDIAL-INFARCTION

被引：16

作者：

MARSHALL, T ^{[1
]}

WILLIAMS, J ^{[1
]}

WILLIAMS, KM ^{[1
]}

机构：

[1] GEN HOSP,DEPT BIOCHEM,SLIGO,IRELAND

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 569卷 / 1-2期

关键词：

D O I：

10.1016/0378-4347(91)80236-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The clinical significance of the serum enzymes creatine kinase (CK, EC 2.7.3.2), lactate dehydrogenase (LD, EC 1.1.1.27) and aspartate aminotransferase (EC 2.6.1.1), and the isoenzymes CK 1-3 and LD 1-5, in acute myocardial infarction (AMI) is reviewed. Particular attention is given to electrophoretic analysis of the isoenzymes (and the CK isoforms/subforms) following AMI and thrombolytic therapy. Other protein markers for the monitoring of AMI, including myoglobin and muscle contractile proteins, are also discussed and the potential for the detection of new marker proteins using high-resolution two-dimensional electrophoretic methods is demonstrated. Whilst emphasis is placed upon electrophoretic methods the value of complementary immunoassays is acknowledged in order to maintain a balanced perspective.

引用

页码：323 / 345

页数：23

共 197 条

[1] CREATINE-KINASE MM ISOENZYME SUBFORMS IN MYOCARDIUM, CARDIAC LYMPH AND BLOOD AFTER CORONARY-ARTERY OCCLUSION IN DOGS [J].