EFFICACY OF TOLMETIN SODIUM FOR ADHESION PREVENTION IN RABBIT AND RAT MODELS

被引：24

作者：

LEGRAND, EK ^{[1
]}

RODGERS, KE ^{[1
]}

GIRGIS, W ^{[1
]}

STRUCK, K ^{[1
]}

CAMPEAU, JD ^{[1
]}

DIZEREGA, GS ^{[1
]}

KIORPES, TC ^{[1
]}

机构：

[1] UNIV SO CALIF, SCH MED, DEPT OBSTET & GYNECOL, LIVINGSTON REPROD BIOL LAB, LOS ANGELES, CA 90033 USA

来源：

JOURNAL OF SURGICAL RESEARCH | 1994年 / 56卷 / 01期

关键词：

D O I：

10.1006/jsre.1994.1011

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Tolmetin sodium’s efficacy in preventing primary adhesions was evaluated in two adhesion models each in two species: (1) rabbit uterine horn, (2) rat uterine horn, (3) rabbit peritoneal side wall, and (4) rat peritoneal side wall. In each model a single instillation of tolmetin sodium solution into the peritoneal cavity at the time of surgery effectively reduced adhesion formation. This efficacy extended over a wide range of concentrations, volumes, and total dosages, and was similar in rabbits and rats. An aqueous solution of 1 mg/ml tolmetin sodium in 5-15 ml in rabbits and in 3 ml in rats was consistently efficacious in reducing postoperative adhesion formation. © 1994 Academic Press. All rights reserved.

引用

页码：67 / 71

页数：5

共 24 条

[1]

[Anonymous], 1989, FERTIL STERIL, V51, P933

[2] PHOSPHATIDYLCHOLINE PREVENTS POSTOPERATIVE PERITONEAL ADHESIONS - AN EXPERIMENTAL-STUDY IN THE RAT [J].