NON-HODGKINS-LYMPHOMA OF THE BRAIN - CAN HIGH-DOSE, LARGE VOLUME RADIATION-THERAPY IMPROVE SURVIVAL - REPORT ON A PROSPECTIVE TRIAL BY THE RADIATION-THERAPY-ONCOLOGY-GROUP (RTOG) - RTOG-8315

被引:434
作者
NELSON, DF
MARTZ, KL
BONNER, H
NELSON, JS
NEWALL, J
KERMAN, HD
THOMSON, JW
MURRAY, KJ
机构
[1] UNIV ROCHESTER,SCH MED,ROCHESTER,NY 14627
[2] RADIAT THERAPY ONCOL GRP,STAT UNIT,PHILADELPHIA,PA
[3] CHESTER CTY HOSP,DEPT PATHOL,PHILADELPHIA,PA
[4] UNIV PENN,DEPT PATHOL,PHILADELPHIA,PA 19104
[5] HAHNEMANN UNIV,DEPT PATHOL,PHILADELPHIA,PA 19102
[6] ARMED FORCES INST PATHOL,DEPT NEUROPATHOL,WASHINGTON,DC 20306
[7] LOUISIANA STATE UNIV,MED CTR,SCH MED,DEPT PATHOL,NEW ORLEANS,LA 70112
[8] NYU,DIV RADIAT ONCOL,NEW YORK,NY 10003
[9] HALIFAX HOSP,MED CTR,DAYTONA BEACH,FL
[10] LATTER DAY ST HOSP,DEPT RADIAT ONCOL,SALT LAKE CITY,UT 84143
[11] MED COLL WISCONSIN,DEPT RADIAT ONCOL,MILWAUKEE,WI 53226
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1992年 / 23卷 / 01期
关键词
PRIMARY NON-HODGKINS LYMPHOMA OF BRAIN; CNS LYMPHOMA; RETICULUM CELL CARCINOMA OF BRAIN; MICROGLIOMA;
D O I
10.1016/0360-3016(92)90538-S
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Between 1983 and 1987 the Radiation Therapy Oncology Group conducted a prospective phase II study to evaluate survival in primary non-Hodgkin's lymphoma of the brain treated with whole brain irradiation to 40 Gy and a 20 Gy boost to tumor plus a 2 cm margin. Forty-one patients are reported. Full follow-up is available on 35/41 who have died. Six are alive at 8.8-67.2 months from start of radiation therapy with a median followup of 53.9 months. Overall median survival was 11.6 months from start of radiation therapy and 12.2 months from diagnosis, with 48% surviving 1 year and 28% surviving 2 years. Karnofsky Performance Status and age were significant prognostic factors. Patients with a Karnofsky Performance Status of 70-100 had a median survival of 21.1 months compared to 5.6 months for patients with a status of 40-60 (p < .001). Fourteen patients < 60 years of age had a median survival of 23.1 months, while 27 patients greater-than-or-equal-to 60 years of age had a median survival of 7.6 months (log-rank p = .001). Disease recurred in the brain in 25/41 (61%) of the patients, (21/41 in the brain only and 4/41 in the brain plus distant metastases). Despite high dose and large volume irradiation, primary Central Nervous System lymphoma still exhibits excessive mortality, especially in older patients. This paradox of the relative radioresistance of primary Central Nervous System lymphoma remains unresolved.
引用
收藏
页码:9 / 17
页数:9
相关论文
共 44 条
[1]  
BERRY MP, 1981, INT J RADIAT ONCOL, V7, P755
[2]  
BUSH RS, 1977, CANCER TREAT REP, V61, P1129
[3]  
Bush RS, 1982, MALIGNANT LYMPHOMAS, P485
[4]  
CHEN MG, 1979, CANCER, V43, P1245, DOI 10.1002/1097-0142(197904)43:4<1245::AID-CNCR2820430412>3.0.CO
[5]  
2-Z
[6]  
COX DR, 1972, J R STAT SOC B, V34, P187
[7]   HISTOPATHOLOGY OF BING-NEEL SYNDROME [J].
EDGAR, R ;
DUTCHER, TF .
NEUROLOGY, 1961, 11 (03) :239-&
[8]  
FRASER RW, 1985, INT J RADIAT ONCOL, V11, P177
[9]  
FREEMAN C, 1972, CANCER, V29, P252, DOI 10.1002/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO
[10]  
2-#