Genetic Aspects of Metabolic Syndrome of Yakut Ethnic Groups

In this article, we have studied polymorphisms in the genes encoding components of carbohydrate metabolism and fibrinolysis system in Yakuts. Genotypes SNPs rs9939609 gene FTO, rs1137101 gene LEPR, rs1799889 and rs6046 gene SERPINE1 F7 gene were identified in the study group patients with metabolic syndrome (n = 100) and healthy (n = 100). We have revealed that the MS group "+" prevailed polymorphic genotype 4G/4G gene SERPINE1, associated with obesity (p=0,009). The risk of developing MS in the Yakut population became involved with genotype 4G/4G gene SERPINE1 (OR = 3,568; CI 95%: 1,534-8,299). In case of polymorphic variants of other genes we studied the risk of MS has not been identified (OR < 1). There was a statistically significant association of gene polymorphism Gln223Arg LEPR level of total cholesterol (p = 0,038), triglycerides (p = 0,033) and SC (p = 0,030) in Yakut ethnic group. Association analysis of polymorphism -675 5G/4G gene SERPINE1 with MS components in the sample revealed significant differences in anthropometric parameters: BMI (p = 0,016), WC (p = 0,001), the ratio of WC to HC (p=0,019).