SISTER CHROMATID EXCHANGE IN PH1-POSITIVE CHRONIC MYELOCYTIC-LEUKEMIA

被引：23
作者：
BECHER, R
SCHMIDT, CG
THEIS, G
HOSSFELD, DK
机构：
[1] West German Tumor Center, University of Essen Medical School, Department of Internal Medicine, Essen
来源：
INTERNATIONAL JOURNAL OF CANCER | 1979年 / 24卷 / 06期
关键词：
D O I：
10.1002/ijc.2910240602
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The sister chromatid exchange (SCE) frequency in bone‐marrow cells of 12 untreated patients with chronic myelocytic leukemia (CML) was analysed and compared with the SCE frequency in bone‐marrow cells of nine healthy persons. In normal persons the SCE ranged from 3.64 to 5.15 per cell. In CML patients the SCE was significantly lower, ranging from 2.32 to 3.44 per cell. The differences found were unrelated to patients' age and contraction state of the chromosomes. It is suggested that the leukemic process could account for the low SCE rate. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码：713 / 716
页数：4
相关论文
共 14 条
[1]   RATE OF SISTER CHROMATID EXCHANGE IN NORMAL HUMAN-BONE MARROW-CELLS [J].
BECHER, R ;
SCHMIDT, CG ;
THEIS, G ;
HOSSFELD, DK .
HUMAN GENETICS, 1979, 50 (02) :213-216
[2]   MANIFOLD INCREASE IN SISTER CHROMATID EXCHANGES IN BLOOMS SYNDROME LYMPHOCYTES [J].
CHAGANTI, RS ;
SCHONBERG, S ;
GERMAN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (11) :4508-4512
[3]   SISTER CHROMATID EXCHANGES AND CHROMOSOMES IN CHRONIC MYELOGENOUS LEUKEMIA AND CANCER FAMILIES [J].
CHENG, WS ;
MULVIHILL, JJ ;
GREENE, MH ;
PICKLE, LW ;
TSAI, S ;
WHANGPENG, J .
INTERNATIONAL JOURNAL OF CANCER, 1979, 23 (01) :8-13
[4]  
GATTI M, 1979, GENETICS, V91, P255
[5]  
KAKATI S, 1978, CANCER RES, V38, P2918
[6]  
KNUUTILA S, 1978, HEREDITAS, V88, P189
[7]   MYELOID KARYOTYPE AND MALIGNANT PHASE OF CHRONIC GRANULOCYTIC LEUKEMIA [J].
LILLEYMAN, JS ;
POTTER, AM ;
WATMORE, AE ;
COOKE, P ;
SOKOL, RJ ;
WOOD, JK .
BRITISH JOURNAL OF HAEMATOLOGY, 1978, 39 (03) :317-323
[8]   CYTOLOGICAL DETECTION OF MUTAGEN CARCINOGEN EXPOSURE BY SISTER CHROMATID EXCHANGE [J].
PERRY, P ;
EVANS, HJ .
NATURE, 1975, 258 (5531) :121-125
[9]   SISTER CHROMATID EXCHANGE AND CHROMOSOME ABERRATION ANALYSIS WITH USE OF SEVERAL CARCINOGENS AND NON-CARCINOGENS [J].
POPESCU, NC ;
TURNBULL, D ;
DIPAOLO, JA .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (01) :289-293
[10]  
PRIGOGINA EL, 1978, HUM GENET, V41, P143
12