PREVENTION OF AN EARLY REOCCLUSION AFTER THROMBOLYTIC THERAPY OF ACUTE MYOCARDIAL-INFARCTION BY KETANSERIN

被引：0

作者：

BRUNE, S ^{[1
]}

TEBBE, U ^{[1
]}

SCHMIDT, T ^{[1
]}

BENN, HP ^{[1
]}

SEILER, KU ^{[1
]}

KREUZER, H ^{[1
]}

机构：

[1] JANSSEN RES FDN,NEUSS,GERMANY

来源：

CLINICAL PHYSIOLOGY AND BIOCHEMISTRY | 1990年 / 8卷

关键词：

REOCCLUSION; THROMBOLYTIC THERAPY; ACUTE MYOCARDIAL INFARCTION; KETANSERIN;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A problem after successful thrombolytic therapy of acute myocardial infarction is the early occurrence of re-occlusions. An incidence between 10 and 30% is reported. All efforts made so far to reduce the re-occlusion rate using a variety of agents have been disappointing. In a pilot study 20 patients with acute myocardial infarction were treated, in whom a successful lytic therapy with urokinase or rt-PA was documented by means of coronary angiography 90 min after the beginning of treatment. Subsequently the patients were heparinised (thrombin time > 30 s), and in addition the selective serotonin-2 receptor-blocking agent ketanserin was given intravenously (4 mg/h). After 24 h the occurrence of early re-occlusions was investigated by control angiography. None of the 20 patients showed re-occlusions. The degree of stenosis in the infarcted vessel was 72% immediately after lytic therapy, and 68% after 24 h. These preliminary results may suggest a possible reduction in the re-occlusion rate after thrombolytic therapy with a combination of heparin and ketanserin.

引用

页码：81 / 84

页数：4

共 19 条

[1]

AWONTERS F, 1985, DRUG DEVELOP RES, V6, P263

[2] EFFECTS OF KETANSERIN AND MEPYRAMINE ON PLATELET-AGGREGATION AND ON THE UPTAKE OF 5-HYDROXYTRYPTAMINE INTO PLATELETS [J].