MORPHOMETRIC ANALYSIS OF ATRIAL NATRIURETIC PEPTIDE-CONTAINING GRANULES IN ATRIOCYTES OF RATS WITH EXPERIMENTAL CONGESTIVE-HEART-FAILURE

被引：11
作者：
AVRAMOVITCH, N
HOFFMAN, A
WINAVER, J
HARAMATI, A
LEWINSON, D
机构：
[1] TECHNION ISRAEL INST TECHNOL,BRUCE RAPPAPORT FAC MED,DEPT MORPHOL SCI,IL-31096 HAIFA,ISRAEL
[2] TECHNION ISRAEL INST TECHNOL,BRUCE RAPPAPORT FAC MED,DEPT PHYSIOL & BIOPHYS,IL-31096 HAIFA,ISRAEL
[3] GEORGETOWN UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS,WASHINGTON,DC 20007
来源：
CELL AND TISSUE RESEARCH | 1995年 / 279卷 / 03期
关键词：
A-V FISTULA; IMMUNOHISTOCHEMISTRY; ATRIAL NATRIURETIC PEPTIDES; CONGESTIVE HEART FAILURE; ATRIOCYTE; RAT (WISTAR-MUNICH);
D O I：
10.1007/s004410050316
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The morphometric characteristics of atrial natriuretic peptide-containing granules were studied in atrial myoendocrine cells of rats with aorto-caval fistula, an experimental model of congestive heart failure. A total of 6680 granules of control and aorto-caval rats were analyzed by a computerized image analysis system that evaluated the number and sectioned surface area of granules and their subcellular location. Compared with control animals, rats with congestive heart failure displayed a slight increase in the number of peripheral granules, adjacent to the sarcolemma, but not centrally located in the Golgi areas. The mean sectioned surface area of granules in rats with congestive heart failure was about 50% of that in controls, both in the right and left atria. Rats with aortocaval fistula had a higher percent of small granules and lower percent of large granules compared with controls. The data demonstrate different morphometric characteristics in atrial natriuretic peptide-containing granules in atriocytes in rats with experimental congestive heart failure; this may reflect the enhanced synthesis and release of atrial natriuretic peptide in heart failure.
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收藏
页码：575 / 583
页数：9
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