STABILIZATION AND FACILITATED FORMATION OF A BETA-STRUCTURE POLYPEPTIDE BY A POLY(L-GLUTAMIC ACID)-FUNCTIONALIZED MONOLAYER ON WATER

被引：25

作者：

HIGASHI, N ^{[1
]}

SHIMOGUCHI, M ^{[1
]}

NIWA, M ^{[1
]}

机构：

[1] DOSHISHA UNIV,FAC ENGN,DEPT APPL CHEM,KAMIKYO KU,KYOTO 602,JAPAN

来源：

LANGMUIR | 1992年 / 8卷 / 06期

关键词：

D O I：

10.1021/la00042a003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this communication, we describe unprecedented conformational changes of poly(L-glutamic acid) (PLGA) assembling at the air-water interface. On the basis of the results from spreading experiments and circular dichroism measurements for the freshly prepared amphiphile, which consists of a PLGA segment (polymerization degree, 40) and two long alkyl chains, it was found that the stable beta-structure of PLGA could be produced specifically by assembling the PLGA segment at the air-water interface and even under an acidic pH, ambient temperature. The conformation of the PLGA segment could be readily controlled by changing the monolayer phase.

引用

页码：1509 / 1510

页数：2

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