IDENTIFICATION OF RABBIT UTERINE CERVICAL PROCOLLAGENASE ACTIVATOR AS RABBIT MATRIX METALLOPROTEINASE 3 (STROMELYSIN)

被引：7

作者：

ITO, A ^{[1
]}

ITOH, Y ^{[1
]}

SATO, T ^{[1
]}

MORI, Y ^{[1
]}

SUZUKI, K ^{[1
]}

NAGASE, H ^{[1
]}

机构：

[1] UNIV KANSAS, MED CTR, DEPT BIOCHEM & MOLEC BIOL, KANSAS CITY, KS 66103 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1991年 / 99卷 / 02期

关键词：

D O I：

10.1016/0305-0491(91)90058-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. We previously reported an endogenous activator of procollagenase from the culture medium of rabbit uterine cervical fibroblasts (Ishibashi et al. (1987) Biochem. J. 241, 527-534). 2. Similar activator was also purified and characterized from rabbit synovial fibroblasts (Vater et al. (1983) J. biol. Chem. 258, 9374-9382), but its mode of activation of procollagenase was reported to be different from that of purified activator from uterine cervical fibroblasts. 3. Here we report the comparative studies of the two activators of procollagenase and demonstrate that they are identified as matrix metalloproteinase 3 (stromelysin) by their immunological and functional criteria. The specific role of the activator in procollagenase activation is also described.

引用

页码：381 / 385

页数：5

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