Fatty acid binding proteins 4 and 5 in overweight prepubertal boys: effect of nutritional counselling and supplementation with an encapsulated fruit and vegetable juice concentrate

被引:9
作者
Canas, Jose A. [1 ]
Damaso, L. [1 ]
Hossain, J. [2 ]
Balagopal, P. Babu [3 ]
机构
[1] Nemours Childrens Specialty Care, Pediat Endocrinol & Metab, Jacksonville, FL 32207 USA
[2] Nemours Childrens Specialty Care, Bioinformat Core Facil, Jacksonville, FL 32207 USA
[3] Nemours Childrens Specialty Care, Biomed Res, Jacksonville, FL 32207 USA
来源
JOURNAL OF NUTRITIONAL SCIENCE | 2015年 / 4卷
关键词
Obesity; Children; Fatty acid binding proteins; beta-Carotene;
D O I
10.1017/jns.2015.29
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Elevated fatty acid binding proteins (FABP) may play a role in obesity and co-morbidities. The role of nutritional interventions in modulating these levels remains unclear. The aim of this post hoc study was to determine the effect of overweight (OW) on FABP4 and FABP5 in boys in relation to indices of adiposity, insulin resistance and inflammation, and to investigate the effects of a 6-month supplementation with an encapsulated fruit and vegetable juice concentrate (FVJC) plus nutritional counselling (NC) on FABP levels. A post hoc analysis of a double-blind, randomised, placebo-controlled study of children recruited from the general paediatric population was performed. A total of thirty age-matched prepubertal boys (nine lean and twenty-one OW; aged 6-10 years) were studied. Patients received NC by a registered dietitian and were randomised to FVJC or placebo capsules for 6 months. FABP4, FABP5, glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), glucose-induced acute insulin response (AIR), lipid-corrected beta-carotene (LC beta C), adiponectin, leptin, high-sensitivity C-reactive protein (hs-CRP), IL-6 and body composition by dual-energy X-ray absorptiometry were determined before and after the intervention. FABP were higher (P < 0.01) in the OW v. lean boys and correlated directly with HOMA-IR, abdominal fat mass (AFM), hs-CRP, IL-6, and LC beta C (P < 0.05 for all). FABP4 was associated with adiponectin and AIR (P < 0.05). FVJC plus NC reduced FABP4, HOMA-IR and AFM (P < 0.05 for all) but not FABP5. OW boys showed elevated FABP4 and FABP5, but only FABP4 was lowered by the FVJC supplement.
引用
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页数:8
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