LIPOSOME-ADMINISTERED OR LDL-ADMINISTERED ZN(II)-PHTHALOCYANINE AS A PHOTODYNAMIC AGENT FOR TUMORS .1. PHARMACOKINETIC PROPERTIES AND PHOTOTHERAPEUTIC EFFICIENCY

被引：130
作者：
REDDI, E
ZHOU, C
BIOLO, R
MENEGALDO, E
JORI, G
机构：
[1] UNIV PADUA, DEPT BIOL, VIA LOREDAN 10, I-35131 PADUA, ITALY
[2] CHINESE ACAD MED SCI, INST CANC, BEIJING, PEOPLES R CHINA
来源：
BRITISH JOURNAL OF CANCER | 1990年 / 61卷 / 03期
关键词：
D O I：
10.1038/bjc.1990.89
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The pharmacokinetics of Zn-phthalocyanine (Zn-Pc) in mice bearing a transplanted MS-2 fibrosar coma has been studied using dipalmitoyl-phosphatidylcholine (DPPC) liposomes and low density lipoproteins (LDL) as drug delivery systems. LDL induce a higher Zn-Pc uptake by the tumour and improve the selectivity of tumour targeting as compared to DPPC liposomes. Experimental photodynamic therapy (PDT) of the MS-2 fibrosarcoma has been performed using liposome-delivered Zn-Pc and the efficiency of tumour necrosis has been measured following four different irradiation protocols. We found that Zn-Pc doses as low as 0.07-0.35 mg kg-1 are sufficient for inducing an efficient tumour response that is linearly dependent on the injected dose. The amount of Zn-Pc in the tumour decreases very slowly as a function of time, hence PDT gives satisfactory results even if performed at relatively long time intervals after administration. © Macmillan Press Ltd., 1990.
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页码：407 / 411
页数：5
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