BIOGENIC AMINE-MEDIATED ALTERATION OF PYRIDOXAL-PHOSPHATE FORMATION IN RAT-BRAIN

被引：13
作者：
EBADI, M
GOVITRAPONG, P
机构：
[1] Department of Pharmacology, University of Nebraska College of Medicine, Omaha, Nebraska
来源：
JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 03期
关键词：
D O I：
10.1111/j.1471-4159.1979.tb04569.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abstract— DOPA, dopamine, norepinephrine, tyramine, serotonin, histamine and GABA inhibited pyridoxal kinase; whereas, tyrosine, 5‐hydroxytryptophan, histidine, glutamic acid, hypotaurine and taurine were without inhibitory effects. Tetrahydroisoquinoline derivatives formed from Pictet‐Spengler condensation between DOPA, dopamine and norepinephrine with pyridoxal and pyridoxal phosphate did not inhibit pyridoxal kinase. These results are interpreted to indicate that interaction of biogenic amines and pyridoxal kinase may alter the formation of pyridoxal phosphate which in turn may influence the activity of numerous pyridoxal phosphate dependent enzymatic reactions in brain. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：845 / 853
页数：9
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