GENETIC-LIFE STYLE INTERACTIONS IN TYPE 2 DIABETES MELLITUS DEVELOPMENT: THE PIMA INDIANS STUDY

被引：1
作者：
Urquidez-Romero, Rene [1 ,2 ]
Esparza-Romero, Julian [1 ]
Valencia, Mauro E. [1 ,3 ,4 ]
机构：
[1] AC CIAD, Ctr Invest Alimentac & Desarrollo, Dept Nutr Publ & Salud, Coordinac Nutr, Carretera Victoria Km 0-6, Hermosillo 83000, Sonora, Mexico
[2] UACJ, Inst Ciencias Biomed, Dept Ciencias Salud, Juarez 32310, Chihuahua, Mexico
[3] Univ Sonora, Dept Ciencias Quim Biol, Hermosillo 83000, Sonora, Mexico
[4] CIAD, Rosales & LD, Hermosillo 83000, Sonora, Mexico
来源：
BIOTECNIA | 2015年 / 17卷 / 01期
关键词：
Type; 2; diabetes; Pima Indians; genetic; lifestyles;
D O I：
10.18633/bt.v17i1.17
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Globally, the increase in Type 2 Diabetes (T2D) prevalence represents a complex public health problem, particularly in developing countries, including Mexico. Type 2 diabetes results from an interaction between genetic predisposition and drastic changes in lifestyle. The aim of this review is to explore these interactions on T2D development, using the Mexican and US Pima Indians comparative study as a model; two genetic related groups, living in different environments, and Mexican Pimas and non-Pimas (Blancos) sharing a similar environment, but not the genetics. Study results showed a lower T2D and obesity prevalence in Mexican Pimas when compared with US Pimas. Likewise, Mexican Pimas had lower fat consumption, higher dietary fiber and higher physical activity than their counterparts in the US. The Pima Indians study showed that even in genetically predisposed populations, T2D development could be mainly determined by lifestyle related factors.
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页码：40 / 46
页数：7
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