Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and Disease

被引：45
作者：
Coffin, J. Douglas [1 ]
Homer-Bouthiette, Collin [2 ]
Hurley, Marja Marie [3 ]
机构：
[1] Univ Montana, Missoula, MT 59812 USA
[2] Univ South Carolina, Sch Med, Columbia, SC 29209 USA
[3] Univ Connecticut, Dept Med, UCONN Hlth, Sch Med, Farmington, CT 06030 USA
来源：
JOURNAL OF THE ENDOCRINE SOCIETY | 2018年 / 2卷 / 07期
基金：
美国国家卫生研究院;
关键词：
bone; FGF2; FGF receptors;
D O I：
10.1210/js.2018-00105
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The fibroblast growth factor (FGF) regulatory axis is phylogenetically ancient, evolving into a large mammalian/human gene family of 22 ligands that bind to four receptor tyrosine kinases for a complex physiologic system controlling cell growth, differentiation, and metabolism. The tissue targets for the primary FGF function are mainly in cartilage and in bone for morphogenesis, mineralization, and metabolism. A multitude of complexities in the FGF ligand-receptor signaling pathways have made translation into therapies for FGF-related bone disorders such as osteomalacia, osteoarthritis, and osteoporosis difficult but not impossible. Copyright (c) 2018 Endocrine Society This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).
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收藏
页码：657 / 671
页数：15
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