25-HYDROXYCHOLECALCIFEROL - DIRECT EFFECT ON CALCIUM TRANSPORT

被引：94
作者：
OLSON, EB
DELUCA, HF
机构：
[1] Department of Biochemistry, University of Wisconsin, Madison
来源：
SCIENCE | 1969年 / 165卷 / 3891期
关键词：
D O I：
10.1126/science.165.3891.405
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The perfused small intestine from a vitamin D deficient rat exhibits about one-half the calcium transport of the intestine from a rat given vitamin D. These levels of calcium transport can be maintained for at least 4 hours. Addition of 2.5 micrograms of 25-hydroxycholecalciferol added to the vitamin D deficient intestine via the arterial blood perfusate induces a rise in calcium transport to +D levels within 2 hours. In contrast, 250 micrograms of vitamin D3 given in the same manner has no effect on the calcium transport level over a 4-hour period. These data provide strong evidence that 25-hydroxycholecalciferol represents the metabolically active form of vitamin D3.
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页码：405 / +
页数：1
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