25-HYDROXYCHOLECALCIFEROL - DIRECT EFFECT ON CALCIUM TRANSPORT

被引:94
作者
OLSON, EB
DELUCA, HF
机构
[1] Department of Biochemistry, University of Wisconsin, Madison
关键词
D O I
10.1126/science.165.3891.405
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The perfused small intestine from a vitamin D deficient rat exhibits about one-half the calcium transport of the intestine from a rat given vitamin D. These levels of calcium transport can be maintained for at least 4 hours. Addition of 2.5 micrograms of 25-hydroxycholecalciferol added to the vitamin D deficient intestine via the arterial blood perfusate induces a rise in calcium transport to +D levels within 2 hours. In contrast, 250 micrograms of vitamin D3 given in the same manner has no effect on the calcium transport level over a 4-hour period. These data provide strong evidence that 25-hydroxycholecalciferol represents the metabolically active form of vitamin D3.
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页码:405 / +
页数:1
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