SUBSTANCE-P AND NEUROPSYCHIATRIC DISORDERS - AN OVERVIEW

被引：13
作者：
MALEKAHMADI, P
机构：
[1] Department of Psychiatry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1992年 / 16卷 / 03期
关键词：
TACHYKININS; SUBSTANCE-P; CENTRAL NERVOUS SYSTEM; NEUROTRANSMITTER; NEUROPSYCHIATRIC DISORDERS;
D O I：
10.1016/S0149-7634(05)80206-4
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Substance P (SP) is a naturally-occurring tachykinin peptide isolated from brain tissues and gastrointestinal tract. In the brain, substantia nigra and basal ganglia contain relatively high amounts of substance P. There is evidence suggesting that substance P functions as a neurotransmitter. It has been implicated in the pathophysiology of several neuropsychiatric disorders. Substance P may also serve as a useful tool in studying the effects of antidepressant drugs and electroconvulsive therapy. However, the contribution of substance P to the understanding of neuropsychiatric disorders is far from clear. Future studies should focus on the interactions and coexistence of substance P with other neurotransmitters and neuropeptides.
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页码：365 / 369
页数：5
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