HEPARINOID-ACTIVE SULFATED POLYSACCHARIDES FROM MONOSTROMA-NITIDUM AND THEIR DISTRIBUTION IN THE CHLOROPHYTA

被引：78

作者：

MAEDA, M

UEHARA, T

HARADA, N

SEKIGUCHI, M

HIRAOKA, A

机构：

[1] TOKYO INST IMMUNOPHARMACOL CO,TOSHIMA,TOKYO 171,JAPAN

[2] KYORIN UNIV,SCH HLTH SCI,HACHIOJI,TOKYO 192,JAPAN

[3] NATL DEF MED COLL,DEPT PHARMACOL,TOKOROZAWA,SAITAMA 359,JAPAN

来源：

PHYTOCHEMISTRY | 1991年 / 30卷 / 11期

关键词：

MONOSTROMA-NITIDUM; CHLOROPHYTA; SULFATED SEAWEED POLYSACCHARIDES; HEPARINOIDS; ANTITHROMBIN ACTIVITY; RHAMNAN SULFATE;

D O I：

10.1016/0031-9422(91)80076-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood anticoagulant activity, especially antithrombin time, was examined with hot water extracts containing seaweed polysaccharides from 23 different species of the Chlorophyta. No correlation between this activity and the systematic positions of the species was found. A remarkably high activity was found in extracts from Monostroma nitidum, and the active polysaccharide was purified by chromatography to yield a ca six-fold higher activity than that of standard heparin. The active material obtained was a high rhamnose-containing sulphated polysaccharide.

引用

页码：3611 / 3614

页数：4

共 16 条

[1]

ABELFATTAH AF, 1974, CARBOHYD RES, V33, P9

[2]

DISCHE Z, 1947, J BIOL CHEM, V167, P189

[3] COLORIMETRIC METHOD FOR DETERMINATION OF SUGARS AND RELATED SUBSTANCES [J].