STRUCTURE ASSIGNMENT TO BIOLOGICALLY PRODUCED MALATHION MONOCARBOXYLIC ACID ISOMERS WITH C-13 NUCLEAR MAGNETIC-RESONANCE

被引：6

作者：

WELLING, W ^{[1
]}

DEVRIES, AW ^{[1
]}

HOUX, NWH ^{[1
]}

JONGEN, WMF ^{[1
]}

SMIT, P ^{[1
]}

VANVELDHUIZEN, A ^{[1
]}

机构：

[1] STATE AGR UNIV,DEPT ORGAN CHEM,WAGENINGEN,NETHERLANDS

来源：

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 1979年 / 10卷 / 01期

关键词：

D O I：

10.1016/0048-3575(79)90008-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical synthesis of malathion α- and β-monocarboxylic acid yields a mixture of the two structural isomers. These two isomers were separated by preparative anion-exchange chromatography on QAE-Sephadex. 13C-Nuclear magnetic resonance of the pure components shows that the main product is the β-isomer, with the α-isomer being present in much smaller quantities. This result was used for identification of hydrolytic malathion metabolites produced by rat tissues. On incubation of malathion with rat liver fractions in vitro it was found that α- and β-monoacid are formed in a ratio of 3:2, whereas this ratio is 9:2 for the metabolites excreted into the urine after intraperitoneal injection of malathion in rats. © 1979.

引用

页码：60 / 66

页数：7

共 8 条

[1]

CASSADAY JT, 1951, Patent No. 2578652

[2] STRUCTURE OF BIOLOGICALLY PRODUCED MALATHION MONOACID [J].