STUDIES ON ACTIVELY ALLERGIZED CELLS .2. INDUCTION ON GUINEA-PIG LYMPHOCYTES OF SPECIFIC RECEPTORS TO A SOLUBLE POLYPEPTIDE ANTIGEN (RABBIT IGG FAB')

被引：26
作者：
WILSON, AB
MUNRO, A
COOMBS, RRA
机构：
[1] Department of Pathology and Biochemistry Department, University of Cambridge, Cambridge
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1969年 / 35卷 / 03期
关键词：
D O I：
10.1159/000230174
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
(1) A proportion of lymphocytes in auricular lymph nodes of guinea pigs injected with rabbit Fab’ intradermally in both ears develop specific receptor sites on their cell surface. (2) These specifically reacting cells have been enumerated and characterized as to size (and cytology) following a single and second injection of rabbit Fab’. The responses had the characteristics of a primary and secondary response respectively. The response to a single injection of sheep erythrocytes had the qualities of a secondary response. (3) The interaction between specifically reacting lymphocytes and erythrocytes carrying Fab' antigen can be inhibited by pre-treatment of the lymphocyte suspension with soluble Fab’. (4) Any significant role of macrophage-cytophilic antibody in the experimental results has been excluded. © 1969 S. Karger AG, Basel.
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页码：228 / &
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[2]   STUDIES ON ACTIVELY ALLERGIZED CELLS .I. CYTO-DYNAMICS AND MORPHOLOGY OF ROSETTE-FORMING LYMPH NODE CELLS IN MICE AND INHIBITION OF ROSETTE-FORMATION WITH ANTIBODY TO MOUSE IMMUNOGLOBULINS [J].
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INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1969, 35 (03) :209-+
[3]   SEPARATION OF UNIVALENT FRAGMENTS FROM THE BIVALENT RABBIT ANTIBODY MOLECULE BY REDUCTION OF DISULFIDE BONDS [J].
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