A PRACTICAL SYNTHESIS OF 5-(CHLOROMETHYL)FURO[2,3-B]PYRIDINE, A KEY INTERMEDIATE FOR THE HIV PROTEASE INHIBITOR, L-754,394

被引：36

作者：

BHUPATHY, M ^{[1
]}

CONLON, DA ^{[1
]}

WELLS, KM ^{[1
]}

NELSON, JR ^{[1
]}

REIDER, PJ ^{[1
]}

ROSSEN, K ^{[1
]}

SAGER, JW ^{[1
]}

VOLANTE, RP ^{[1
]}

DORSEY, BD ^{[1
]}

HOFFMAN, JM ^{[1
]}

JOSEPH, SA ^{[1
]}

MCDANIEL, SL ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS,DEPT MED CHEM,W POINT,PA 19486

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 04期

关键词：

D O I：

10.1002/jhet.5570320431

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from commercially available methyl 2-furoate.

引用

页码：1283 / 1287

页数：5

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