BUPRENORPHINE REDUCES CEREBRAL GLUCOSE-METABOLISM IN POLYDRUG ABUSERS

被引：23

作者：

WALSH, SL

GILSON, SF

JASINSKI, DR

STAPLETON, JM

PHILLIPS, RL

DANNALS, RF

SCHMIDT, J

PRESTON, KL

GRAYSON, R

BIGELOW, GE

SULLIVAN, JT

CONTOREGGI, C

LONDON, ED

机构：

[1] NATL INST DRUG ABUSE,ADDICT RES CTR,NEUROIMAGING & DRUG ACT SECT,BALTIMORE,MD 21224

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,BALTIMORE,MD 21205

[5] JOHNS HOPKINS UNIV,SCH MED,DEPT ANESTHESIOL,BALTIMORE,MD

[6] UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201

来源：

NEUROPSYCHOPHARMACOLOGY | 1994年 / 10卷 / 03期

关键词：

OPIOID; BUPRENORPHINE; GLUCOSE METABOLISM; DRUG ABUSE; HUMAN BRAIN IMAGING;

D O I：

10.1038/npp.1994.18

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Buprenorphine is a mixed opioid agonist-antagonist, which acts as a partial mu agonist and a kappa antagonist. The present study evaluated the acute effects of buprenorphine on cerebral glucose metabolism (CMRglc) in six human substance abusers using a double-blind, placebo-controlled, counterbalanced, crossover design. Each subject participated in two positron emission tomographic (PET) studies, 1 week apart, following the injection of buprenorphine (1 mg, intramuscularly) and placebo. Buprenorphine significantly reduced CMRglc and the regional cerebral metabolic rate for glucose (rCMRglc) by up to 32% in all but three of 22 bilateral and in 4 midline regions (p < .05). No region showed an increase in rCMRglc. Buprenorphine also produced miosis, respiratory depression, and subjective ratings of euphoria and sedation in comparison to placebo (p < .05). These observations extend previous findings of reduced CMRglc following acute treatment with morphine and other nonopioid euphorigenic drugs.

引用

页码：157 / 170

页数：14

共 54 条

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