INTRACELLULAR FREE [CA2+] AND [NA+] IN RESPONSE TO CAPSAICIN IN CULTURED DORSAL-ROOT GANGLION-CELLS

被引：13
|
作者：
AKERMAN, KEO [1 ]
GRONBLAD, M [1 ]
机构：
[1] UNIV HELSINKI,CENT HOSP,BACK PAIN RES UNIT,SF-00290 HELSINKI 29,FINLAND
来源：
NEUROSCIENCE LETTERS | 1992年 / 147卷 / 01期
关键词：
DORSAL ROOT GANGLION NEURON; CAPSAICIN; NA+; CA2+; FURA-2; SBFI;
D O I：
10.1016/0304-3940(92)90763-W
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intracellular free Ca2+ and Na+ concentrations in cultured rat dorsal root ganglion cells were studied using the intracellular fluorescent probes fura-2 and SBFI, respectively. Capsaicin increased both intracellular [Ca2+] and [Na+]. A rise in cytosolic free Ca2+ could still be seen if Na+ was removed from the outer medium. The results suggest that capsaicin opens up ion channels which are permeable both to Ca2+ and Na+.
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页码：13 / 15
页数：3
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