CATALYTIC ASYMMETRIC NITROALDOL REACTION - AN EFFICIENT SYNTHESIS OF (S) PROPRANOLOL USING THE LANTHANUM BINAPHTHOL COMPLEX

被引：140

作者：

SASAI, H ^{[1
]}

ITOH, N ^{[1
]}

SUZUKI, T ^{[1
]}

SHIBASAKI, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 05期

关键词：

D O I：

10.1016/0040-4039(93)89031-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Propranolol, a more potent optical isomer of the widely used beta-blocker, was conveniently synthesized in a highly enantioselective manner by the lanthanum-(R)-(+)-binaphthol complex catalyzed asymmetric nitroaldol reaction.

引用

页码：855 / 858

页数：4

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